Oxidative aromatization of 1,4-dihydropyridines and pyrazolines using HbA-H2O2: An efficient biomimetic catalyst system providing metabolites of drug candidates

Article abstract of DOI:10.1016/j.bmcl.2009.05.056

Human hemoglobin (HbA) efficiently catalyses the oxidative aromatization of 1,4-dihydropyridines (1,4-DHPs) and pyrazolines with hydrogen peroxide in phosphate buffer. The results of the study reveal that the rates of oxidative aromatization of 1,4-DHPs a