Tetrahedron Letters p. 5719 - 5722 (1995)
Update date:2022-08-03
Topics:
Park, Jeongho
Min, Changhee
Williams, Howard
Scotf
As potential inhibitors of oxidosqualene cyclase (OSC) (±)-(15E)&(15Z)-16-oxa-2,3-oxidosqualenes ((9)&(10)) were synthesized by the Wittig-Horner reaction from diphenylphosphinoyl-1-ethyl-geranyl ether (5) and the epoxy aldehyde (6). An efficient synthetic method for the Wittig-Horner reagent (5) was developed.
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