Chemical and Pharmaceutical Bulletin p. 424 - 426 (1997)
Update date:2022-08-03
Topics:
Endo, Yasuyuki
Ohno, Michihiro
Takehana, Shunji
Driedger, Paul E.
Stabel, Silvia
Shudo, Koichi
We synthesized benzolactams with hydrophobic substituents at various positions as analogs of (-)-benzolactam-V8-310 ((-)-BL-V8-310, 1) which reproduces the active conformation and biological activity of teleocidins. Structure-activity data indicate that the existence of a hydrophobic region between C-2 and C-9, and the steric factor at C-8 play critical roles in the appearance of biological activities.
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