A concise synthesis of (R)-GABOB from L-malic acid

Article abstract of DOI:10.1080/00397919508011784

A concise synthesis of (R)-4-amino-3-hydroxybutanoic acid, starting from L-malic acid, is reported. The approach is based on the conversion of the oxazolidin-2-one 9 into a full protected form of (R)-GABOB by an Anrdt-Eistert reaction.

Full text of DOI:10.1080/00397919508011784

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A Concise Synthesis of (R)-
GABOB from L-Malic Acid
Domenico Misiti a , Giovanni Zappia a & Giuliano
Delle Monache b
a Dip. di Studi di Chimica e Technologia delle
Sostanze Biologicamente Attive , Università “La
Sapienza” , P. le A. Moro 5, 00185, Roma, (Italy)
b Centro di Studio per la Chimica dei Recettori del
C.N.R., Istituto di Chimica, Università Cattolica del
S. Cuore , Largo F. Vito 1, 00168, Roma, (Italy)
Published online: 23 Sep 2006.
To cite this article: Domenico Misiti , Giovanni Zappia & Giuliano Delle
Monache (1995) A Concise Synthesis of (R)-GABOB from L-Malic Acid, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 25:15, 2285-2294, DOI: 10.1080/00397919508011784
To link to this article: http://dx.doi.org/10.1080/00397919508011784
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