Synthetic studies on the key component of the new generation of quinolonecarboxylic acid, DU-6859. 1. Synthesis of (1R,2S)-2-fluorocyclopropylamine by the use of optical resolution

DOI: 10.1016/S0040-4020(01)89665-4

Source and publish data:

Tetrahedron p. 3889 - 3904 (1994)

Update date:2022-08-04

Topics:

Authors:

Tamura, Osamu

Hashimoto, Masaru

Kobayashi, Yuko

Katoh, Tadashi

Nakatani, Kazuhiko

Kamada, Masahiro

Hayakawa, Isao

Akiba, Toshifumi

Terashima, Shiro

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(01)89665-4

The title synthesis was achieved by employing highly cis-selective cyclopropanation of N-benzyl-N-vinylcarbamates with zinc-monofluorocarbenoid, deprotection of the formed N-benzyl-N-(cis-2-fluorocyclopropyl)carbamates, and optical resolution of the resul

Full text of DOI:10.1016/S0040-4020(01)89665-4

Products guided by the article

Product name:N-(diphenylmethyl)ethanimine

Cas No:169698-45-7

R&D Labs maybe for 169698-45-7

Hubei ShiNan Pharmaceutical Chemical co., Ltd.(expird)

Contact:+86-13554447107

Address:Wuhan HongShanOu wu no road 378 future residence building 1 unit 14 layer no. 1401 A
HEZE KINGVOLT CHEMICAL CO., LTD

Contact:86-573-82118911

Address:Juancheng Industry Park
Hangzhou Ocean Chemical Co., Ltd.

website:http://www.hzoceanchem.com

Contact:+86-571-88025872, 28272092, 28272096

Address:Room 623 ,Building No 1 , COFCO Radius Commercial Center Xiwen Road, Xiacheng District, Hangzhou, Zhejiang Province, China
Ji'an Hairui Natural Plant Co. Ltd.

Contact:0796-8105528

Address:Meilin industry park, Qingyuan district Ji'an City, Jiangxi Province
A-Chem Technologies Co.,Ltd.

Contact:+86-512-69561895

Address:No.111, Building A4, 218 Xinghu Street, Suzhou Industrial Park, P. R. China

Relevant to this article

Use of the oxazole-olefin Diels-Alder reaction in the total synthesis of the monoterpene alkaloids (-)-plectrodorine and (+)-oxerine

Doi:10.1248/cpb.54.63
(2006)
Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells

Doi:10.3390/md12073818
(2014)
3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents.

Doi:10.1016/S0968-0896(02)00016-0
(2002)
An efficient protocol for the preparation of primary alcohols bearing a β-chiral center via an oxazolidinone auxiliary mediated resolution, and application to the synthesis of 4,4-disubstituted piperidine substance P antagonists

Doi:10.1021/jo9918246
(2000)
Selective and potent monoamine oxidase type B inhibitors: substituted semicarbazones and acylhydrazones of aromatic aldehydes and ketones

Doi:10.1016/0223-5234(96)88258-4
(1995)
Titanocene(II)-promoted olefination of ω,ω-bis(phenylthio)alkyl alkanoates. A new method for the preparation of ω-hydroxy ketones

Doi:10.1016/S0040-4020(99)01091-1
(2000)

Article Doi