Synthetic studies on the key component of the new generation of quinolonecarboxylic acid, DU-6859. 1. Synthesis of (1R,2S)-2-fluorocyclopropylamine by the use of optical resolution

DOI: 10.1016/S0040-4020(01)89665-4

Source and publish data:

Tetrahedron p. 3889 - 3904 (1994)

Update date:2022-08-04

Topics:

Authors:

Tamura, Osamu

Hashimoto, Masaru

Kobayashi, Yuko

Katoh, Tadashi

Nakatani, Kazuhiko

Kamada, Masahiro

Hayakawa, Isao

Akiba, Toshifumi

Terashima, Shiro

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Article abstract of DOI:10.1016/S0040-4020(01)89665-4

The title synthesis was achieved by employing highly cis-selective cyclopropanation of N-benzyl-N-vinylcarbamates with zinc-monofluorocarbenoid, deprotection of the formed N-benzyl-N-(cis-2-fluorocyclopropyl)carbamates, and optical resolution of the resul

Full text of DOI:10.1016/S0040-4020(01)89665-4

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