2'- and/or 3'-deoxy-β-L-pentofuranosyl nucleoside derivatives: Stereospecific synthesis and antiviral activities

Article abstract of DOI:10.1080/15257779508012437

Several L-enantiomers of nucleoside analogues were stereospecifically synthesized by a multi-step reaction from L-xylose and their antiviral properties were examined in vitro. Two of them, namely β-L-2',3,'- dideoxycytidine (β-L-ddC) and its 5-fluoro derivative (β-L-FddC) were found to have potent anti-human immunodeficiency virus (HIV) and significant antihepatitis B virus (HBV) activities in cell cultures.

Full text of DOI:10.1080/15257779508012437

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2′-and/or 3Y-Deoxy-β-L-pentofuranosyl
Nucleoside Derivatives: Stereospecific
Synthesis and Antiviral Activities
Gilles Gosselin a , Christophe Mathé a , Marie-Christine Bergogne a
, Anne-Marie Aubertin b , Andre Kirn b , Jean-Pierre Sommadossi c ,
Raymond Schinazi d & Jean-Louis Imbach a
a Laboratoire de Chimie Bio-organique, URA 488 CNRS , Universitéa
de Montpellier II , 34095, Montpellier Cedex, 5
b Universitéa Louis Pasteur, INSERM U 74 , 67000, Strasbourg, France
c Department of Pharmacology , University of Alabama ,
Birmingham, AL, 35294
d Veterans Affairs Medical Center , Decatur, GA, 30033, USA
Published online: 16 Feb 2007.
To cite this article: Gilles Gosselin , Christophe Mathé , Marie-Christine Bergogne , Anne-Marie
Aubertin , Andre Kirn , Jean-Pierre Sommadossi , Raymond Schinazi & Jean-Louis Imbach (1995) 2′-
and/or 3Y-Deoxy-β-L-pentofuranosyl Nucleoside Derivatives: Stereospecific Synthesis and Antiviral
Activities, Nucleosides and Nucleotides, 14:3-5, 611-617
To link to this article: http://dx.doi.org/10.1080/15257779508012437
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