2'- and/or 3'-deoxy-β-L-pentofuranosyl nucleoside derivatives: Stereospecific synthesis and antiviral activities

Article abstract of DOI:10.1080/15257779508012437

Several L-enantiomers of nucleoside analogues were stereospecifically synthesized by a multi-step reaction from L-xylose and their antiviral properties were examined in vitro. Two of them, namely β-L-2',3,'- dideoxycytidine (β-L-ddC) and its 5-fluoro derivative (β-L-FddC) were found to have potent anti-human immunodeficiency virus (HIV) and significant antihepatitis B virus (HBV) activities in cell cultures.