Thiopyranoindoles as Inhibitors of 5-Lipoxygenase, 5-Lipoxygenase-Activating Protein, and Leukotriene C4 Synthase

DOI: 10.1021/jm00022a020

Source and publish data:

Journal of Medicinal Chemistry p. 4538 - 4547 (1995)

Update date:2022-08-04

Topics:

Authors:

Hutchinson, John H.

Charleson, Stella

Evans, Jilly F.

Falgueyret, Jean-Pierre

Hoogsteen, Karst

et al. et al.

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Article abstract of DOI:10.1021/jm00022a020

The attachment of an arylacetic or benzoic acid moiety to the thiopyrano<2,3,4-c,d>indole nucleus results in compounds which are highly potent and selective 5-lipoxygenase (5-LO) inhibitors.These compounds are structurally simpler than previous compounds

Full text of DOI:10.1021/jm00022a020

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