Novel 2-amino-1,4-dihydropyridine calcium antagonists. I. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having nitroxyalkoxycarbonyl groups at 3- and/or 5-position

DOI: 10.1248/cpb.43.788

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 788 - 796 (1995)

Update date:2022-07-30

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Authors:

Kobayashi

Inoue Inoue

Kita Kita

Yoshiya Yoshiya

Nishino Nishino

Oizumi Oizumi

Kimura Kimura

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Article abstract of DOI:10.1248/cpb.43.788

Novel 2-amino-1,4-dihydropyridine derivatives, which contain nitroxy-alkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their pharmaceutical effect was evaluated in spontaneously hypertensive rats. The structure-activity relationships are discussed in terms of potency, onset-rapidity, and duration of antihypertensive activity. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced on either side of an ester chain.

Full text of DOI:10.1248/cpb.43.788

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