Novel 2-amino-1,4-dihydropyridine calcium antagonists. I. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having nitroxyalkoxycarbonyl groups at 3- and/or 5-position

DOI: 10.1248/cpb.43.788

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 788 - 796 (1995)

Update date:2022-07-30

Topics:

Authors:

Kobayashi

Inoue Inoue

Kita Kita

Yoshiya Yoshiya

Nishino Nishino

Oizumi Oizumi

Kimura Kimura

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.43.788

Novel 2-amino-1,4-dihydropyridine derivatives, which contain nitroxy-alkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their pharmaceutical effect was evaluated in spontaneously hypertensive rats. The structure-activity relationships are discussed in terms of potency, onset-rapidity, and duration of antihypertensive activity. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced on either side of an ester chain.

Full text of DOI:10.1248/cpb.43.788

NII-Electronic Library Service

Products guided by the article

Product name:2-nitroxypropyl 2-(2-nitrobenzylidene)acetoacetate

Cas No:170749-00-5

R&D Labs maybe for 170749-00-5

Zhejiang kehong chemical co., ltd

Contact:0086-575-85522000

Address:xiner center RD binhai industrial zone shaoxing zhejiang province P.R.China,312073
Nanjing Raise Pharmatech Co., Ltd

website:http://www.raisechem.com

Contact:+86-25-58649566

Address:B381,No.606,Ningliu Road,Jiangbei New Area,Nanjing,Jiangsu Province,China
Ji'an Hairui Natural Plant Co. Ltd.

Contact:0796-8105528

Address:Meilin industry park, Qingyuan district Ji'an City, Jiangxi Province
ChangZhou Mascotchem. Co.,Ltd.

website:http://www.mascotchem.com

Contact:86-519-85010339

Address:B-802,XingBei Building,391#,Tongjiang Middle Road New District,Changzhou,JS,China
Beijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)

Contact:010-52876516

Address:tongzhoubeiyuan

Relevant to this article

Synthesis of 2′-N-methylamino-2′-deoxyguanosine and 2′- N, N-dimethylamino-2′-deoxyguanosine and their incorporation into RNA by phosphoramidite chemistry

Doi:10.1021/jo201364x
(2011)
Structure-activity relationships and molecular modelling of 5-arylidene-2,4-thiazolidinediones active as aldose reductase inhibitors

Doi:10.1016/j.bmc.2005.02.026
(2005)
A chiral pool approach to the synthesis of optically active tetrahalo norbornyl building blocks

Doi:10.1021/ol800990m
(2008)
Antiaromatic spacer-bridged bisfluorenyl dications generated by superacid induced ionization

Doi:10.1021/ja711501k
(2008)
Novel bisquinoline antimalarials. Synthesis, antimalarial activity, and inhibition of haem polymerisation

Doi:10.1016/0006-2952(96)00306-1
(1996)
New N-aryl-N′-(3-(substituted)phenyl)-N′-methylguanidines as leads to potential PET radioligands for imaging the open NMDA receptor

Doi:10.1016/j.bmcl.2014.11.066
(2015)

Article Doi