A new chiral disulfonamide ligand derived from α-amino acid for catalytic enantioselective cyclopropanation

Article abstract of DOI:10.1016/S0040-4039(97)00038-5

A new disulfonamide prepared from α-amino acid in five steps catalyzed cyclopropanation of allylic alcohols with Et₂Zn and CH₂I₂ to afford the corresponding cyclopropylmethanols in moderate to good enantioselectivites. In particular, the reaction of cinnamyl alcohol in the presence of a chiral disulfonamide 1k afforded an excellent enantioselectivity (85% ee).