Diastereoselective Preparation of Chiral Lithiated Allyl Amines: Application in EPC-Synthesis

Article abstract of DOI:10.1016/0957-4166(95)00271-P

Lithiation of chiral allylamine (R)-1 with BuⁿLi and Bu^tLi leads to the formation of intermediate (R)-2, which by reaction with D2O, Me2CO or (CH2)5CO affords the expected chiral compounds (R)-3, (R)-4 and (R)-5, respectively.With Bu