Synthesis and antitumor activity of duocarmycin derivatives

DOI: 10.1248/cpb.43.1530

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1530 - 1535 (1995)

Update date:2022-08-03

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Authors:

Nagamura

Kanda Kanda

Kobayashi

Gomi Gomi

Saito Saito

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Article abstract of DOI:10.1248/cpb.43.1530

A series of duocarmycin B2 derivatives, modified at the phenolic hydroxyl group to ester, carbonate and carbamate, was synthesized. Antitumor activity of these analogs was preliminarily evaluated by assays of growth inhibition of HeLa S3 cells (in vitro)

Full text of DOI:10.1248/cpb.43.1530

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