Novel and Efficient Synthesis of 1β-Methylcarbapenems Utilizing Cyclization of Hypervalent Iodonium Ylides

Article abstract of DOI:10.1016/0040-4039(95)01703-K

1β-Methylcarbapenems were efficiently synthesized utilizing acid- and rhodium(II)-catalyzed cyclization of iodonium ylide intermediates, which were easily prepared from the corresponding β-keto ester derivatives.