Journal of Organic Chemistry p. 5814 - 5819 (1995)
Update date:2022-08-03
Topics:
Karp, Gary M.
A series of 7-, 8-, and 9-bromo- and iodo-1,4-benzodiazepine-2,5-diones have been prepared and examined as substrates for palladium(II)-mediated coupling reactions with alkenes, alkynes, arylstannanes, and heteroarylstannanes.The benzodiazepinediones 6a,e,g were prepared from the reaction of o-nitrobenzoyl chlorides 3a-c and methyl tert-butylglycinate followed by nitro reduction and cyclization.Regioselective halogenation gave 6c,d,f.Bromo- and iodobenzodiazepinediones 6c,d,f,g were then converted to alkenyl-, alkynyl-, aryl-, and heteroaryl-substituted benzodiazepinediones in moderate to good yield in the presence of palladium(II).
View MoreTaizhou KEDE Chemical.Co.,Ltd.
Contact:86-576-84613060
Address:Jiangkou Chemical Zoon
Taizhou Huading Chemical Co.,Ltd(expird)
Contact:+86-576-88583898
Address:Economic&Technology development zone,Taizhou City,Zhejiang Province,China
Contact:+44 (0)161 367 9441
Address:
Changyi Xinxing Technology Development Co., Ltd.
Contact:0086-510-86651065(Time Zone:8),86651656
Address:94 Yingbinxilu WestRoad, Huangtu Town, Jiangyin City, Jiangsu, China
Wuhan Hanye Chemical New Material Co.,Ltd
Contact:+86-27-85308141
Address:LiuDian, Panlongcheng Economic Development Zone, HuangPi district, Wuhan, Hubei 430311 P.R.China
Doi:10.1016/0040-4020(95)00657-T
(1995)Doi:10.1080/00397919508015485
(1995)Doi:10.1248/cpb.43.1598
(1995)Doi:10.1021/jo01052a532
(1962)Doi:10.1016/j.tetlet.2007.08.087
(2007)Doi:10.1021/jo00129a029
(1995)