Improved total synthesis and structure-activity relationship of arenastatin A, a potent cytotoxic spongean depsipeptide

DOI: 10.1248/cpb.43.1598

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1598 - 1600 (1995)

Update date:2022-08-03

Topics:

Authors:

Kobayashi

Wang Wang

Ohyabu Ohyabu

Kurosu Kurosu

Kitagawa

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Article abstract of DOI:10.1248/cpb.43.1598

An efficient asymmetric synthesis of a cyclic depsipeptide arenastatin A (1) is described. 1, isolated from the marine sponge Dysidea arenaria, exhibited extremely potent cytotoxicity with IC₅₀ of 5 pg/ml for KB cells, and in this context the s

Full text of DOI:10.1248/cpb.43.1598

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