European Journal of Medicinal Chemistry p. 617 - 626 (1995)
Update date:2022-08-03
Topics:
Baji, H.
Flammang, M.
Kimny, T.
Gasquez, F.
Compagnon, P. L.
Delcourt, A.
A novel series of (1-aryl-2-heterocyclyl)ethylideneaminooxymethyl-substituted dioxolanes IIIa-n were synthesized by condensation of substituted 1,3-dioxolan-4-ylmethyl p-toluenesulfonates 4 with 1-(hydroxyimino)-1-aryl-2-heterocyclylethanes 5.Compounds IIIa-n were found to have effective in vitro antifungal activity when evaluated against the pathogenic fungi Candida albicans, Aspergillus flavus and Fusarium solani with MIC (minimum inhibitory concentration values of 10 μg*ml-1 for IIIa-l and 5 μg*ml-1 for IIIm,n. antifungal activity / 1,3-dioxolane / ethylideneaminooxy / imidazole / 1,2,4-triazole
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Doi:10.1002/anie.201914851
(2020)Doi:10.1007/BF02219066
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(1995)
