Enantiospecific Synthesis of (3R,4R)-3-Amino-1-Hydroxy-4-Methyl Pyrrolidin-2-one (L-687,414), an NMDA Receptor Antagonist

DOI: 10.1016/0040-4020(95)00719-O

Source and publish data:

Tetrahedron p. 11581 - 11594 (1995)

Update date:2022-07-29

Topics:

Authors:

Baldwin, Jack E.

Adlington, Robert M.

Elend, Almut S.

Smith, Marie L.

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Article abstract of DOI:10.1016/0040-4020(95)00719-O

An enantiospecific synthesis of the NMDA receptor antagonist (3R,4R)-3-amino-1-hydroxy-4-methylpyrrolidin-2-one via ring opening of the chiral β-lactam (9) is reported.

Full text of DOI:10.1016/0040-4020(95)00719-O

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