Enantiospecific Synthesis of (3R,4R)-3-Amino-1-Hydroxy-4-Methyl Pyrrolidin-2-one (L-687,414), an NMDA Receptor Antagonist

DOI: 10.1016/0040-4020(95)00719-O

Source and publish data:

Tetrahedron p. 11581 - 11594 (1995)

Update date:2022-07-29

Topics:

Authors:

Baldwin, Jack E.

Adlington, Robert M.

Elend, Almut S.

Smith, Marie L.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4020(95)00719-O

An enantiospecific synthesis of the NMDA receptor antagonist (3R,4R)-3-amino-1-hydroxy-4-methylpyrrolidin-2-one via ring opening of the chiral β-lactam (9) is reported.

Full text of DOI:10.1016/0040-4020(95)00719-O

Products guided by the article

Product name:(3S,4R)-t-butyl N-(benzyloxycarbonyl)azetidin-3-methyl-2-one-4-carboxylate

Cas No:172749-34-7

R&D Labs maybe for 172749-34-7

Tianjin Boron PharmaTech Co.,Ltd.(expird)

Contact:86-022-59845187

Address:B9-401, Tianda Science Park,No.80,4th Avenue,TEDA,Tianjin, China
Shanghai shibo Chemical Co., Ltd

Contact:+86-021-60753516

Address:688 Qiushi Road, Jinshan High-tech Park, Shanghai, China,201512
Suzhou Wedo Chemicals Co., Ltd.

Contact:86 512 58100425

Address:Zonger Road, DongSha Industry Park , Zhangjiagang, Jiangsu, China
Huangshan Violet Biological Technology Co., Ltd

Contact:+86-559-2335676

Address:16-201 JinShanYuan,JiangNan New City,TunXi District,HuangShan City,AnHui Province,China
Taiwan Surfactant Corp.

Contact:886 2 2541 0022

Address:8 Fl., No. 11, Sec. 1, Chung Shan North Rd., Taipei, Taiwan R.O.C.

Relevant to this article

A highly stereocontrolled, four-step synthesis of (±)-lasubine II

Doi:10.1021/ja00230a026
(1988)
A Convenient Synthesis of 3-Chloromethyl-2(3H)-benzothiazolones

Doi:10.1055/s-1988-27616
(1988)
Stereoselective Reactions. XXIV. Chlorotrimethylsilane Promoted Asymmetric Michael Reaction of Chiral Lithioenamines Derived from α-Alkyl β-Keto Esters

Doi:10.1016/S0040-4020(01)89317-0
(1994)
A facile synthesis of (+)-L-discadenine and its deuterio derivatives

Doi:10.1055/s-1988-27529
(1988)
Doi:10.1021/ja01545a060
(1958)
The Synthesis of (+)-Hedycaryol, Starting from Natural (-)-Guaiol

Doi:10.1016/S0040-4020(01)85014-6
(1994)

Article Doi