European Journal of Medicinal Chemistry p. 769 - 778 (1995)
Update date:2022-08-03
Topics:
Yebga, A.
Menager, S.
Verite, P.
Farnoux, C. Combet
Lafont, O.
In order to study the competition between hepatic hydroxylation and desulfuration in the thiobarbiturate series, two compounds bearing a branched side chain with a tertiary carbon atom in position ω-1 were administered to rats over about one week.Urine and faeces were collected and extracted.The metabolites isolated were identified.It was shown that desulfuration was not the major metabolic pathway, and that, when it took place, it remained a minor process and was accompanied by γ-hydroxylation into a tertiary alcohol. thiobarbiturate series / metabolism / oxidation / desulfuration
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