Synthesis, determination of enantiomeric purity and structural characterisation of enantiopure (2R,5R)-(+)-2,5-bis-(diphenylphosphino)-hexane, a chiral DPPB analogue

Article abstract of DOI:10.1016/0957-4166(96)00016-X

Enantiopure (2R,5R)-(+)-2,5-bis-(diphenylphosphino)hexane, 3, a chiral analogue of 1,4-bis-(diphenylphosphino)butane was synthesized in two steps from enantiomerically pure (2S,5S)-(+)-hexanediol. The molecular structure of (2R,5R)-3 was determined by X-ray structure analysis of its nickel-(II)-complex showing a rare dimeric species; NMR analysis of the reaction product of 3 with (+)-di-μ-chloro-bis-{2-[1-(dimethylamino)ethyl]phenyl-C,N}-dipallad ium allowed to deduce the enantiomeric purity.