Synthesis p. 1355 - 1356 (1995)
Update date:2022-08-03
Topics:
Li
Soucy-Breau
Ouimet
An improved synthesis of Flosulide (1), a selective COX-2 inhibitor, from the cheap and commercially available 4-chloro-3-nitrobenzaldehyde (2) by using an intramolecular Friedel-Crafts reaction of 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid (7) as the key step is reported.
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Doi:10.1021/jm950707+
(1996)Doi:10.1016/S0022-1139(00)81443-8
(1982)Doi:10.1021/jo00100a016
(1994)Doi:10.1002/recl.19951141107
(1995)Doi:10.1016/S0040-4020(01)88837-2
(1967)Doi:10.1016/0040-4020(95)00980-9
(1996)
