Improved synthesis of a selective COX-2 inhibitor, 6-(2,4-difluorophenoxy)-5-methane-sulfonamidoindan-1-one (flosulide)

Article abstract of DOI:10.1055/s-1995-4129

An improved synthesis of Flosulide (1), a selective COX-2 inhibitor, from the cheap and commercially available 4-chloro-3-nitrobenzaldehyde (2) by using an intramolecular Friedel-Crafts reaction of 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid (7) as the key step is reported.