4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

DOI: 10.1016/S0960-894X(02)00312-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2023 - 2026 (2002)

Update date:2022-07-29

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Authors:

Spencer, Jeffrey R

McGee, Danny

Allen, Darin

Katz, Bradley A

Luong, Christine

Sendzik, Martin

Squires, Neil

Mackman, Richard L

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Article abstract of DOI:10.1016/S0960-894X(02)00312-8

The structure-based design of potent and selective urokinase-type plasminogen activator (uPA) inhibitors with 4-aminoarylamidine or 4-aminoarylguanidine S1 binding groups, is described.

Full text of DOI:10.1016/S0960-894X(02)00312-8

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