Journal of the Chemical Society. Perkin Transactions 2 (2001) p. 789 - 794 (1996)
Update date:2022-07-31
Topics:
Jakas, Andreja
Horvat, Stefica
The N-(1-deoxy-D-fructos-1-yl) derivatives (Amadori compounds) of the endogenous opioid pentapeptide, leucine-enkephalin (11), leucine-enkephalin methyl ester (12) and of structurally related peptides (9, 10) are synthesized. The equilibrium compositions of the prepared Amadori compounds 9-12 in D 2O and [2H6]DMSO are determined using 13C NMR spectroscopy. In water, the β-pyranose, α-furanose and β-furanose forms are detected, the β-pyranose tautomer being the most abundant at equilibrium (67-75%). The α-pyranose form and open-chain keto form are not detected. In dimethyl sulfoxide, the equilibrium compositions of 9-12 are markedly shifted towards a higher proportion of furanose forms, amounting to two-thirds of the mixture. In addition to the α- and β-furanoses and β-pyranose tautomers, DMSO solutions of compounds 9-12 contain at equilibrium a relatively high proportion of the acyclic hydrate (gem-diol) form (ca. 10%).
View Moreshijiazhuang alkay chemicals co..ltd(expird)
Contact:86-311-67692035
Address:2601,juntang building,qiaodong district,shijiazhuang
Contact:+91 9963263336
Address:Plot#146A, IDA Mallapur, Hyderabad - 500072
Zhushan County Tianxin Pharmaceutical & Chemical Co., Ltd.
Contact:0086-719-4224892
Address:Tutang Road, Chengguan Town, Zhushan County, Hubei Province
Huangshan Honghui Pharm Technology Co., Ltd.(expird)
website:http://www.honghuichem.com
Contact:18855958372
Address:Qingshan Wan No.1,Nanyuan Kou,SheXian Huangshan City,Anhui Province
NINGBO YINZHOU PRECISE COLOR CO.,LTD.
Contact:86-574-88139809 86-574-83033159
Address:Qiming Road,Yinzhou,Ningbo,China
Doi:10.1016/S0968-0896(00)00121-8
(2000)Doi:10.1021/ja00406a026
(1981)Doi:10.1016/j.bmc.2017.12.008
(2018)Doi:10.1021/ja01514a060
()Doi:10.1016/S0957-4166(00)00014-8
(2000)Doi:10.1016/S0040-4039(00)00018-6
(2000)
