Synthesis and estrogen receptor binding affinities of the major human metabolites of raloxifene (LY139481)

DOI: 10.1016/S0960-894X(97)00142-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 993 - 996 (1997)

Update date:2022-08-05

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Authors:

Dodge, Jeffrey A.

Lugar, Charles W.

Cho, Stephen

Osborne, John J.

Phillips, David L.

Glasebrook, Andrew L.

Frolik, Charles A.

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Article abstract of DOI:10.1016/S0960-894X(97)00142-X

Glucuronide conjugates 1 and 2, the major metabolites of raloxifene, have been prepared and their molecular interactions with the estrogen receptor determined.

Full text of DOI:10.1016/S0960-894X(97)00142-X

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Product name:Methyl-1-(4’-tert-butyldimethylsylyl-6-hydroxyraloxifene)-2,3,4-tri-O-acetyl--D-glycopyranuronate

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