Synthesis of a non-hydrolyzable AZT-triphosphate analogue designed for the production of anti-AZT-TP antibodies

DOI: 10.1016/S0040-4039(99)00497-9

Source and publish data:

Tetrahedron Letters p. 3391 - 3394 (1999)

Update date:2022-08-03

Topics:

Authors:

Brossette, Thierry

Valleix, Alain

Goujon, Laure

Creminon, Christophe

Grassi, Jacques

Mioskowski, Charles

Lebeau, Luc

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Article abstract of DOI:10.1016/S0040-4039(99)00497-9

An enzymatically stable analogue of AZT-triphosphate is prepared in 7 steps starting from thymidine. The thymine moiety is functionalized at N³ to allow the further cross-linking to a carrier protein for subsequent immunization of rabbits in order to raise specific antibodies directed against AZT-TP.

Full text of DOI:10.1016/S0040-4039(99)00497-9

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Product name:3'-azido-3'-deoxy-5'-O-(4-methoxybenzoyl)-N³-{1-[5-(2,2,2,-trifluoroacetylamino)pentyl]}thymidine

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