Bioorganic and Medicinal Chemistry p. 2111 - 2120 (1997)
Update date:2022-08-03
Topics:
Lien, Jin-Cherng
Huang, Li-Jiau
Wang, Jih-Pyang
Teng, Che-Ming
Lee, Kuo-Hsiung
Kou, Sheng-Chu
A series of 2-substituted 3-chloro-1,4-naphthoquinones was synthesized, and the antiplatelet, antiinflammatory, and antiallergic activities of these compounds were evaluated. The structure-activity relationships in this series were also examined. Most of the 2-alkyl/arylcarboxamido derivatives of 3-chloro-1,4-naphthoquinone showed potent activities with similar trends in each of the activities evaluated.
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