Tetrahedron p. 1129 - 1134 (1994)
Update date:2022-08-05
Topics:
Shi, Guo-qiang
Takagishi, Sadahito
Schlosser, Manfred
The mixture of lithium diisopropylamide and potassium tert-butoxide ("LIDA-KOR reagent") is a powerful base which can be advantageously employed for the regioselective deprotonation of fluoropyridines and, in particular, 3-fluoroquinoline.A novel cyclization process was elaborated for the preparation of the latter product.
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