Metalated Fluoropyridines and Fluoroquinolines as Reactive Intermediates: New Ways for Their Regioselective Generation

Article abstract of DOI:10.1016/S0040-4020(01)80824-3

The mixture of lithium diisopropylamide and potassium tert-butoxide ("LIDA-KOR reagent") is a powerful base which can be advantageously employed for the regioselective deprotonation of fluoropyridines and, in particular, 3-fluoroquinoline.A novel cyclization process was elaborated for the preparation of the latter product.