Protoberberines from Reissert-Compounds, V [1]: Synthesis of (±)-Bharatamine

Article abstract of DOI:10.1007/BF00807398

Alkylation of the Reissert compound 1 by methyl 2-bromomethylbenzoate (2) followed by spontaneous intramolecular cyclization affords dibenzo[a, g]quinolizinone 4 which in turn can be reduced to benzyl ether 5 by LiAlH₄/NaBH₄. Debenzy