Synthesis and evaluation of 2-aryl-4H-3,1-benzoxazin-4-ones as C1r serine protease inhibitors

DOI: 10.1016/0960-894X(96)00094-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 679 - 682 (1996)

Update date:2022-08-03

Topics:

Authors:

Gilmore, John L.

Hays, Sheryl J.

Caprathe, Bradley W.

Lee, Chitase

Emmerling, Mark R.

Michael, Walter

Jaen, Juan C.

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Article abstract of DOI:10.1016/0960-894X(96)00094-7

A series of 2-aryl-4H-3,1-benzoxazin-4-ones have been synthesized and tested for inhibitory activity against C1r serine protease. Compounds were found that were equipotent and more selective than the reference compound FUT-175.

Full text of DOI:10.1016/0960-894X(96)00094-7

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