New antifolate 4,4'-diaminodiphenyl sulfone substituted 2,4-diamino-5-benzylpyrimidines. Proof of their dual mode of action and autosynergism

DOI: 10.1002/ardp.19963290309

Source and publish data:

Archiv der Pharmazie p. 161 - 168 (1996)

Update date:2022-08-04

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Authors:

Wiese Wiese

Schmalz Schmalz

Seydel Seydel

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Article abstract of DOI:10.1002/ardp.19963290309

New 4,4'-diaminodiphenylsulfone substituted 2,4-diamino-5-benzylpyrimidines were synthesized. These compounds are highly active inhibitors of both bacterial dihydrofolate reductase (DHFR) and dihydropteroic acid synthase (SYN). The simultaneous inhibition

Full text of DOI:10.1002/ardp.19963290309

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