
Archiv der Pharmazie p. 161 - 168 (1996)
Update date:2022-08-04
Topics:
Wiese
Schmalz
Seydel
New 4,4'-diaminodiphenylsulfone substituted 2,4-diamino-5-benzylpyrimidines were synthesized. These compounds are highly active inhibitors of both bacterial dihydrofolate reductase (DHFR) and dihydropteroic acid synthase (SYN). The simultaneous inhibition
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(1989)