New antifolate 4,4'-diaminodiphenyl sulfone substituted 2,4-diamino-5-benzylpyrimidines. Proof of their dual mode of action and autosynergism

DOI: 10.1002/ardp.19963290309

Source and publish data:

Archiv der Pharmazie p. 161 - 168 (1996)

Update date:2022-08-04

Topics:

Authors:

Wiese Wiese

Schmalz Schmalz

Seydel Seydel

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/ardp.19963290309

New 4,4'-diaminodiphenylsulfone substituted 2,4-diamino-5-benzylpyrimidines were synthesized. These compounds are highly active inhibitors of both bacterial dihydrofolate reductase (DHFR) and dihydropteroic acid synthase (SYN). The simultaneous inhibition

Full text of DOI:10.1002/ardp.19963290309

Products guided by the article

Product name:4-Methyl-N-[3-methyl-4-(4-nitro-phenylsulfanyl)-phenyl]-benzenesulfonamide

Cas No:176512-26-8

R&D Labs maybe for 176512-26-8

Jiangsu Seed Chem Co.,Ltd.

Contact:86-513-84128750/13773795976

Address:No.48.Youyi West Road ,Rudong Development Zone,Jiangsu Province,China
Zouping Fuhai Technology Development Co., Ltd.

Contact:+0532-86934525 18660293207

Address:jiuhu town industrial park Zouping County,bingzhou Provincejiuhu town industrial park
Jiangxi Hito Chemical Co., Ltd.

Contact:+86-792-3170318

Address:No. 6, Tianhong Ave., Xinghuo Industry Park, Yongxiu, Jiujiang, Jiangxi, China
Hangzhou Zyter Biological & Chemical Technology Co., Ltd.

website:http://www.zyterpharm.com

Contact:+86-18858184290

Address:West Wenyi Road, Cangqian, Yuhang
Suzhou CarbonWell Pharma-Tech Co., Ltd

Contact:Tel: + 86 (0)512-8898-1216; + 86-18606258602

Address:2358 Changan Road, Wujiang Scientific Innovation Park, Wujiang, Jiangsu Province, P. R. China 215200

Relevant to this article

New urinary metabolites formed from ring-oxidized metabolic intermediates of styrene

Doi:10.1021/tx9004192
(2010)
Diorganotin(IV) dithiocarbamate complexes as chromogenic sensors of anion binding

Doi:10.1016/j.poly.2009.09.010
(2009)
Hydride, hydrogen, proton, and electron affinities of imines and their reaction intermediates in acetonitrile and construction of thermodynamic characteristic graphs (TCGs) of imines as a molecule ID card

Doi:10.1021/jo902332n
(2010)
Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain

Doi:10.1021/acs.jmedchem.1c00367
(2021)
Novel and convenient to substituted imidazoles

Doi:10.1002/jhet.213
(2009)
Azido Glycols: Potent, Low Molecular Weight Renin Inhibitors Containing an Unusual Post Scissile Site Residue

Doi:10.1021/jm00126a038
(1989)

Article Doi