The enantiospecific synthesis of functionalised pipecolic acids as constrained analogues of lysine

Article abstract of DOI:10.1016/0040-4039(96)00140-2

Two constrained analogues of (S)-lysine have been prepared, suitably protected for solid phase peptide synthesis, in high potential optical and diastereomeric purity. The key step is the alkylation of the 6-oxopipecolate derivative (6) with iodoacetonitri