Stereoselective synthesis of a pyridoxamine coenzyme-amino acid chimera: Assembly of a polypeptide incorporating the pyridoxamine moiety

Article abstract of DOI:10.1016/0040-4039(96)00207-9

The stereoselective synthesis of (S)-2-amino-N(α)-(fluorenylmethoxycarbonyl)-3-(α⁴,3-O-bis-tert-buto xycarbonylpyridoxamin-5-yl)propanoic acid (4) was accomplished from pyridoxamine dihydrochloride. A key step is the stereoselective alkylation