Tetrahedron Letters p. 3395 - 3398 (1996)
Update date:2022-08-05
Topics:
Wang, Jing
De Clercq, Pierre J.
The estradiol derived enyne 2 is obtained via a nine step sequence starting from estrone. Key-steps involve the opening of the α-epoxide 7 and the 1,2-addition of propargylmagnesium bromide on the allene ketone 10. The allylic alcohol 2 possesses the requ
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