Thalidomide analogs and PDE4 inhibition

DOI: 10.1016/S0960-894X(98)00475-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2669 - 2674 (1998)

Update date:2022-08-04

Topics:

Authors:

Muller, George W.

Shire, Mary G.

Wong, Lu Min

Corral, Laura G.

Patterson, Rebecca T.

Chen, Yuxi

Stirling, David I.

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Article abstract of DOI:10.1016/S0960-894X(98)00475-2

N-Phthaloyl 3-amino-3-arylpropionic acid analogs of thalidomide that are potent inhibitors of tumor necrosis factor-α are reported. These compounds were found to be potent inhibitors of phosphodiesterase 4.

Full text of DOI:10.1016/S0960-894X(98)00475-2

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