Bioorganic and Medicinal Chemistry Letters p. 1035 - 1036 (1996)
Update date:2022-08-05
Topics:
Zhang
Berger
Ulrich
Because toxic metabolites are formed by microsomal oxidative cleavage of the ether methylenes of the antiprotozoal drug, pentamidine, we synthesized the previoulsy unreported analogue of pentamidine in which the ether oxygens are replaced by methylenes. Although this compound was about 20-fold less active than pentamidine against Trypanosoma brucei infection in mice, it did not undergo oxidative cleavage, suggesting a new direction for design of less toxic pentamidine analogues.
View MoreDongying J&M Chemical Co., Ltd,
Contact:546-8551108
Address:Room 1219, Zisheng Mansion, Zibo Road, Dongying, Shandong, China
website:http://www.maisonchem.com.cn
Contact:0086-311-83833777
Address:Leitou industrial district, xinji, shijiazhuang city, hebei province,
Qingdao S. H. Huanyu Imp. & Exp. Co., Ltd.
Contact:86-532-88250866
Address:Room 615, World Trade Centre Building B, Hongkong Middle Roda 6#, Qingdao, Shandong, China
website:http://www.mascot-ie.com
Contact:86-519-85010339
Address:B-802,XingBei Building,391#,Tongjiang Middle Road New District,Changzhou,JS,China
Shouguang Nuomeng Chemical Co., Ltd.
Contact:+86-536-5119508/18363669993
Address:Hou Zhen Industrial Park, Shouguang, Shandong, China
Doi:10.1007/BF00905368
()Doi:10.1002/cber.19961290517
(1996)Doi:10.1021/jm200460q
(2011)Doi:10.1016/S0968-0896(98)00252-1
(1999)Doi:10.1021/ja954171t
(1996)Doi:10.1039/c2cc31406a
(2012)