Bioorganic and Medicinal Chemistry Letters p. 1035 - 1036 (1996)
Update date:2022-08-05
Topics:
Zhang
Berger
Ulrich
Because toxic metabolites are formed by microsomal oxidative cleavage of the ether methylenes of the antiprotozoal drug, pentamidine, we synthesized the previoulsy unreported analogue of pentamidine in which the ether oxygens are replaced by methylenes. Although this compound was about 20-fold less active than pentamidine against Trypanosoma brucei infection in mice, it did not undergo oxidative cleavage, suggesting a new direction for design of less toxic pentamidine analogues.
View MorePINGYUAN SIHUAN PHARMACEUTICAL CO., LTD
Contact:+86-531-55696072
Address:#2766,yinxiu Road, Economic Development Zone, Pingyuan Country, Shandong Province, China.
Beijing Wisdom Chemicals Co., Ltd.
Contact:+86-10-52350335
Address:F2, BLDG 19, Liando Valley U, Majuqiao, Tongzhou District, Beijing, China
Reliable Pharma Technology (Shanghai) Co., Ltd.
Contact:0086-21-67676847-8008
Address:Lane 1500, No.68, Xinfei Road, Songjiang District, Shanghai, 201611, P.R.China.
website:http://www.apeptides.com/en/
Contact:+86-21-60871011
Address:No. 80 Chuanshan Shuyuan Steet,Pudong,Shanghai
Binzhou Holly Pharmaceutical Co.,Ltd.
Contact:74517
Address:No.15 Dapu Road,Huangpu District Shanghai,P.R.China
Doi:10.1007/BF00905368
()Doi:10.1002/cber.19961290517
(1996)Doi:10.1021/jm200460q
(2011)Doi:10.1016/S0968-0896(98)00252-1
(1999)Doi:10.1021/ja954171t
(1996)Doi:10.1039/c2cc31406a
(2012)