Conformationally restricted analogues of methionine: Synthesis of chiral 3-amino-5-methylthio-2-piperidones

DOI: 10.1016/S0040-4020(96)00340-7

Source and publish data:

Tetrahedron p. 7727 - 7736 (1996)

Update date:2022-08-05

Topics:

Authors:

Rodriguez, Ricardo

Estiarte, M. Angels

Diez, Anna

Rubiralta, Mario

Colell, Anna

Garcia-Ruiz, Carmen

Fernandez-Checa, Jose C.

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Article abstract of DOI:10.1016/S0040-4020(96)00340-7

(αR, 3RS, 5S)-3-Amino-N-(2-hydroxy-1-phenylethyl)-5-methylthio-2- piperidones 1 have been synthesized from enamide 2 by subsequent free radical addition of methanothiol on position 5 and amination of 3-position.

Full text of DOI:10.1016/S0040-4020(96)00340-7

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