
Tetrahedron p. 8099 - 8112 (1996)
Update date:2022-09-26
Topics:
Ohkubo, Mitsuru
Nishimura, Teruyuki
Jona, Hideki
Honma, Teruki
Morishima, Hajime
A practical method for the synthesis of an indolo[2,3-a]pyrrolo[3,4- c]carbazole ring system is described. The method involves two key processes: a coupling reaction between indole and substituted methylmaleimide portions using lithium hexamethyldisilazide (LiHMDS) as a base, and the oxidative cyclization of bisindolylmaleimide with palladium (II) chloride. We applied this method to the synthesis of arcyriaflavin B (5), C (6) and D (7).
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Doi:10.1002/hlca.19940770604
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(1990)Doi:10.1248/cpb.41.636
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