Synthesis and NMR spectra of some new carbohydrate modified uridine phosphoramidites

Article abstract of DOI:10.1080/07328319708006222

The one step reaction of 2'- and 3'-keto derivatives of uridine with bromodifluoromethyl[tris(dimethylamino)]phosphonium bromide and zinc gives the corresponding 2'- and 3'-difluoromethylene nucleosides in good yield. Desilylation and phosphitylation of the resultant 2'- or 3'-hydroxyls provides the target 2'- and 3'-phosphoramidites 7 and 8 for use in oligonucleotide synthesis.

Full text of DOI:10.1080/07328319708006222

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Synthesis and NMR Spectra of Some
New Carbohydrate Modified Uridine
Phosphoramidites
Pawel J. Serafinowski a & Colin L. Barnes a
a CRC Centre for Cancer Therapeutics at the Institute of Cancer
Research , 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
Published online: 16 Aug 2006.
To cite this article: Pawel J. Serafinowski & Colin L. Barnes (1997) Synthesis and NMR Spectra of
Some New Carbohydrate Modified Uridine Phosphoramidites, Nucleosides and Nucleotides, 16:7-9,
1529-1532, DOI: 10.1080/07328319708006222
To link to this article: http://dx.doi.org/10.1080/07328319708006222
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