Bioorganic and Medicinal Chemistry Letters p. 511 - 514 (1997)
Update date:2022-09-26
Topics:
Hirst, Gavin C.
Queen, Kennedy L.
Sugg, Elizabeth E.
Willson, Timothy M.
The CCK antagonists RP 69758 and (R)-lorglumide were converted into CCK agonists by the introduction of an N-isopropylanilide agonist 'trigger'. The common structural features of these ligands suggest that nonpeptide agonists and antagonists bind to a common site in the CCK receptor.
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