A highly enantioselective synthesis of (R)- and (S)-5,7-odimethyleucomol

Article abstract of DOI:10.1016/S0040-4039(00)97181-8

Both (R)- and (S)-5,7-O-dimethyleucomol 1b (R = Me) were synthesized in 57% overall yield in>96% enantiomeric excess. The key step involves the enantioselective α hydroxylation of the lithium enolate of 8 by readily available (+)- and (-)-[(8,8-dimethoxyc