Imidazole and triazole substituted ether phospholipids: Potent antitumor agents

Article abstract of DOI:10.1016/S0960-894X(97)00433-2

Two novel ether phospholipids containing an imidazole and a triazole at the C-2 position of the glyceryl chain, respectively, were synthesized and evaluated as antitumor agents. Both compounds inhibited the growth of a number of tumor cell lines in vitro; IC₅₀ values ranged from 1 to 6 μM for MCF-7, MDA-MB-231, HT-29 and HL-60 tumor cell lines.