Bioorganic and Medicinal Chemistry Letters p. 2379 - 2382 (1997)
Update date:2022-08-03
Topics:
Nair, Haridasan K.
Peterson, Andrew C.
Yazdi, Parvin T.
Franzmair, Rudolf
Two novel ether phospholipids containing an imidazole and a triazole at the C-2 position of the glyceryl chain, respectively, were synthesized and evaluated as antitumor agents. Both compounds inhibited the growth of a number of tumor cell lines in vitro; IC50 values ranged from 1 to 6 μM for MCF-7, MDA-MB-231, HT-29 and HL-60 tumor cell lines.
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