Chemical and Pharmaceutical Bulletin p. 1196 - 1201 (1996)
Update date:2022-08-05
Topics:
Harada, Naoyuki
Hongu, Mitsuya
Kawaguchi, Takayuki
Ohohashi, Motoaki
Oda, Kouji
Hashiyama, Tomiki
Tsujihara, Kenji
In an attempt to improve the effectiveness of action of 5-fluoro-2'- deoxyuridine (FUdR), various kinds of O-alkylated water-soluble analogues were synthesized. Antitumor activities against sarcoma 180 (solid) were also evaluated. Some compounds exhibited potent activities. In particular, 3'-O- p-chlorobenzyl-3-N-aminoacyloxy-methylester derivatives were effective over a very wide range of dose and gave extremely large therapeutic ratios compared with known 5-fluorouracil (5-FU) derivatives.
View MoreTianjin Jingye Fine Chemicals Co., Ltd.
Contact:+86-15722078107; +86-22-26911407
Address:Bohua Fine Chemicals Base of Petrochemical Industry Park, Nanhuan Road, Dagang District, Tianjin, 300271, P. R. China
Changzhou Hopschain Chemical Co.,Ltd
website:http://www.hopschem.cn/products.html
Contact:86-519-85528066
Address:Room 710, Unit A, Xingbei Development Mansion, Tongjiang Road, Changzhou City,213000, China
Antaeus Bio-technology Co., LTD(expird)
Contact:021-31252569
Address:shanghai pudong
Hangzhou Showland Technology Co., Ltd.
Contact:86-571-88920516
Address:ROOM2118,NO.553,WENSAN ROAD,HANGZHOU,CHINA
Hangzhou Zyter Biological & Chemical Technology Co., Ltd.
website:http://www.zyterpharm.com
Contact:+86-18858184290
Address:West Wenyi Road, Cangqian, Yuhang
Doi:10.1246/bcsj.27.582
(1954)Doi:10.1021/jo960401q
(1996)Doi:10.1007/BF00909138
()Doi:10.1039/b303041e
(2003)Doi:10.1021/ja01635a043
()Doi:10.1246/bcsj.69.1763
(1996)
