Chemical and Pharmaceutical Bulletin p. 1196 - 1201 (1996)
Update date:2022-08-05
Topics:
Harada, Naoyuki
Hongu, Mitsuya
Kawaguchi, Takayuki
Ohohashi, Motoaki
Oda, Kouji
Hashiyama, Tomiki
Tsujihara, Kenji
In an attempt to improve the effectiveness of action of 5-fluoro-2'- deoxyuridine (FUdR), various kinds of O-alkylated water-soluble analogues were synthesized. Antitumor activities against sarcoma 180 (solid) were also evaluated. Some compounds exhibited potent activities. In particular, 3'-O- p-chlorobenzyl-3-N-aminoacyloxy-methylester derivatives were effective over a very wide range of dose and gave extremely large therapeutic ratios compared with known 5-fluorouracil (5-FU) derivatives.
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(2003)Doi:10.1021/ja01635a043
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(1996)
