Chemical and Pharmaceutical Bulletin p. 1196 - 1201 (1996)
Update date:2022-08-05
Topics:
Harada, Naoyuki
Hongu, Mitsuya
Kawaguchi, Takayuki
Ohohashi, Motoaki
Oda, Kouji
Hashiyama, Tomiki
Tsujihara, Kenji
In an attempt to improve the effectiveness of action of 5-fluoro-2'- deoxyuridine (FUdR), various kinds of O-alkylated water-soluble analogues were synthesized. Antitumor activities against sarcoma 180 (solid) were also evaluated. Some compounds exhibited potent activities. In particular, 3'-O- p-chlorobenzyl-3-N-aminoacyloxy-methylester derivatives were effective over a very wide range of dose and gave extremely large therapeutic ratios compared with known 5-fluorouracil (5-FU) derivatives.
View MoreHangzhou Sartort Biopharma Co., Ltd
website:http://www.sartort.com
Contact:86-571-87039693
Address:No. 57, Tech Park Road, Hangzhou, Zhejiang, China
Xiamen Huasing Chemicals Co.Ltd.
Contact:0086-592-6228397
Address:NO.24, Xinglin North 2nd Road,Jimei district
Shandong Xinhua Pharmaceutical Co.,Ltd
website:http://www.xhzy.com
Contact:+86-533-2196801
Address:1 lutai road,zhangdian dis,Zibo City
Contact:0311-13263231263
Address:jian hua street,Shijiazhuang City, China
suzhou chukai pharmateach co,.ltd
Contact:86-512-88812511
Address:Building 3, Wujiang Scientific Innovation Park, 2358 Changan Rd, Wujiang 215200, Jiangsu Province, P. R. China
Doi:10.1246/bcsj.27.582
(1954)Doi:10.1021/jo960401q
(1996)Doi:10.1007/BF00909138
()Doi:10.1039/b303041e
(2003)Doi:10.1021/ja01635a043
()Doi:10.1246/bcsj.69.1763
(1996)
