Chemical and Pharmaceutical Bulletin p. 1196 - 1201 (1996)
Update date:2022-08-05
Topics:
Harada, Naoyuki
Hongu, Mitsuya
Kawaguchi, Takayuki
Ohohashi, Motoaki
Oda, Kouji
Hashiyama, Tomiki
Tsujihara, Kenji
In an attempt to improve the effectiveness of action of 5-fluoro-2'- deoxyuridine (FUdR), various kinds of O-alkylated water-soluble analogues were synthesized. Antitumor activities against sarcoma 180 (solid) were also evaluated. Some compounds exhibited potent activities. In particular, 3'-O- p-chlorobenzyl-3-N-aminoacyloxy-methylester derivatives were effective over a very wide range of dose and gave extremely large therapeutic ratios compared with known 5-fluorouracil (5-FU) derivatives.
View MoreContact:+86-310-7092106
Address:Quzhou Modern & New Industrial Park, Handan, Hebei 057250, China
Chongqing Shuangfeng Chemical Co.,Ltd
Contact:+86-23-49850156
Address:No.663,xuanhua Rd,yongchuan,chongqing,China
website:http://www.sdowchem.com
Contact:86-135-2193 7483
Address:8-106 taiyue building
Contact:+86-0512-69209969
Address:Room 317,Lushan Road,Suzhou New District,Jiangsu Province,China.
website:http://www.konochem.com
Contact:86-29-86107037
Address:No.170 West Avenue,Xi’an 710082,China
Doi:10.1246/bcsj.27.582
(1954)Doi:10.1021/jo960401q
(1996)Doi:10.1007/BF00909138
()Doi:10.1039/b303041e
(2003)Doi:10.1021/ja01635a043
()Doi:10.1246/bcsj.69.1763
(1996)
