Chemical and Pharmaceutical Bulletin p. 1196 - 1201 (1996)
Update date:2022-08-05
Topics:
Harada, Naoyuki
Hongu, Mitsuya
Kawaguchi, Takayuki
Ohohashi, Motoaki
Oda, Kouji
Hashiyama, Tomiki
Tsujihara, Kenji
In an attempt to improve the effectiveness of action of 5-fluoro-2'- deoxyuridine (FUdR), various kinds of O-alkylated water-soluble analogues were synthesized. Antitumor activities against sarcoma 180 (solid) were also evaluated. Some compounds exhibited potent activities. In particular, 3'-O- p-chlorobenzyl-3-N-aminoacyloxy-methylester derivatives were effective over a very wide range of dose and gave extremely large therapeutic ratios compared with known 5-fluorouracil (5-FU) derivatives.
View MoreContact:+86-10-62651721
Address:29 Yongxing Road, Daxing District,Beijing China
LianYunGang Chiral Chemical(CHINA) CO.,LTD
Contact:+86-518-83616958 +86-519-82884848
Address:LianYunGang Chemical Industry Park (JiangSu)
MS( MAOSHENG )Chemical CO.,LTD
Contact:+86-519-82726678.82726378
Address:TAOXI INDUSTRY ZONE JINTAN
Xi'an yuanfar international trade company
website:https://www.yuanfarchemical.com
Contact:86-029-88745613 ext 828
Address:Floor19th ,B Building, Oak Block,No.36 South Fenghui Road, Dev. Zone of High-Tech Ind.,Xi’an, China
Jinhua Haoyuan Chemical CO., LTD(expird)
Contact:86-579-82465583
Address:Jinhua,Zhejiang
Doi:10.1246/bcsj.27.582
(1954)Doi:10.1021/jo960401q
(1996)Doi:10.1007/BF00909138
()Doi:10.1039/b303041e
(2003)Doi:10.1021/ja01635a043
()Doi:10.1246/bcsj.69.1763
(1996)
