Preparation of α-fluoro-β-per(poly) fluoroalkyl-substituted enol ethers

DOI: 10.1016/0022-1139(95)03382-3

Source and publish data:

Journal of Fluorine Chemistry p. 45 - 50 (1996)

Update date:2022-09-26

Topics:

Authors:

Thenappan, Alagappan

Burton, Donald J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0022-1139(95)03382-3

Fluorocarboethoxymethylene tri-n-butylphosphorane, Bu₃P=CFCOOEt (3), reacts with per- and poly-fluoroalkyl-substituted carboxylic acid esters, ethyl formate and γ-butyrolactone to give the corresponding enol ethers, R_FC (OEt)=CFCOOEt (4), in good yield. Non-activated esters failed to react with 3. With the anion derived from ethyl diethylphosphonofluoroacetate, (EtO)₂P(O)CFHCOOEt (5), a mixture of 4 and β-ketoesters, R_FC(O)CFHCOOEt (7), is formed.

Full text of DOI:10.1016/0022-1139(95)03382-3

Products guided by the article

Product name:ethyl 3-ethoxy-2-fluoroacrylate

Cas No:179991-09-4

R&D Labs maybe for 179991-09-4

Hebei Maison Chemical Co.,Ltd

website:http://www.maisonchem.com.cn

Contact:0086-311-83833777

Address:Leitou industrial district, xinji, shijiazhuang city, hebei province,
NEM CHEMICAL CO.，LTD

website:http://www.NEM.COM.CN

Contact:+86-393-4411771

Address:The west section of shengli Road,Puyang,Henan Province,China
Nantong LiKai Chemical Co.,Ltd

Contact:+86-513-89068669

Address:Jincheng Science Park
Tangshan Moneide Trading Co., Ltd.

Contact:+86-315-8309571

Address:2-7-420 Jidong Building Materials Commercial Center, Tangshan, Hebei, 064000 China
Mollt Biochem Co., Ltd(expird)

Contact:+86-21-38682181

Address:shanghai ,china

Relevant to this article

Some new compounds with P(E)NHC(O) (E = lone pair, O, S) linkage: Synthesis, spectroscopic, crystal structures, theoretical studies, and antimicrobial evaluation

Doi:10.1007/s00706-013-0960-4
(2013)
Diastereoselective synthesis of 2-amino-4-phosphonobutanoic acids by conjugate addition of lithiated schoellkopf's bislactim ethers to vinylphosphonates

Doi:10.1021/jo034707q
(2003)
Regioselective nucleophilic substitutions of fluorobenzene derivatives

Doi:10.1016/0040-4039(96)01425-6
(1996)
Exploitation of highly functionalised epoxides derived from asymmetrized tris(hydroxymethyl)methane (THYM*) in the synthesis of a fragment of lasalocide A and other related polyether ionofore antibiotics

Doi:10.1016/0040-4020(96)00751-X
(1996)
A well-defined NHC-Ir(III) catalyst for the silylation of aromatic C-H bonds: Substrate survey and mechanistic insights

Doi:10.1039/c6sc04899d
(2017)
Photosensitive azopolymer brushes via atom transfer radical polymerization for protein sensing

Doi:10.1002/cjoc.201190044
(2011)

Article Doi