An efficient synthesis of C20-C25 building blocks for calyculin A

Article abstract of DOI:10.1016/0040-4020(96)00383-3

The C₂₀-C₂₅ building blocks 2 and 3a for calyculin A, a protein phosphatase inhibitor, have been efficiently prepared from L-malic acid utilizing the Grignard reaction of the Weinreb amides 8 and 14, followed by stereoselective reduction of the ketones 9 and 15, respectively, as the key steps. Copyright