Symmetrical anhydride-type serine protease inhibitors: Structure- activity relationship studies of human chymase inhibitors

DOI: 10.1016/S0960-894X(99)00012-8

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Bioorganic and Medicinal Chemistry Letters p. 413 - 418 (1999)

Update date:2022-07-29

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Authors:

Iijima, Kiyoko

Katada, Jun

Hayashi, Yoshio

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Article abstract of DOI:10.1016/S0960-894X(99)00012-8

We prepared a potent and relatively selective human chymase inhibitor 9 (-), based on the study of SAR of a symmetrical anhydride-type serine protease inhibitor 1. Kinetic studies suggested that 9 (-) reacts with the Ser residue at the active site of the

Full text of DOI:10.1016/S0960-894X(99)00012-8

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