
Bioorganic and Medicinal Chemistry Letters p. 413 - 418 (1999)
Update date:2022-07-29
Topics:
Iijima, Kiyoko
Katada, Jun
Hayashi, Yoshio
We prepared a potent and relatively selective human chymase inhibitor 9 (-), based on the study of SAR of a symmetrical anhydride-type serine protease inhibitor 1. Kinetic studies suggested that 9 (-) reacts with the Ser residue at the active site of the
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