Symmetrical anhydride-type serine protease inhibitors: Structure- activity relationship studies of human chymase inhibitors

Article abstract of DOI:10.1016/S0960-894X(99)00012-8

We prepared a potent and relatively selective human chymase inhibitor 9 (-), based on the study of SAR of a symmetrical anhydride-type serine protease inhibitor 1. Kinetic studies suggested that 9 (-) reacts with the Ser residue at the active site of the