A three-component coupling approach to the marine bis-indole alkaloids: Topsentin, deoxytopsentin and bromotopsentin

Article abstract of DOI:10.1016/0040-4039(96)01148-3

The total syntheses of three marine bis-indole alkaloids (1, 2, 4) of the topsentin family together with the synthesis of unnatural deoxybromotopsentin (33) are described. Key elements include, a 1,2-addition-oxidation sequence to construct the bis-hetero