Bioorganic and Medicinal Chemistry Letters p. 2485 - 2490 (1997)
Update date:2022-07-29
Topics:
Ikeda, Tsuyoshi
Kajimoto, Tetsuya
Kondo, Hirosato
Wong, Chi-Huey
In an effort to develop the structural and functional mimics of the tetrasaccharide sialyl Lewis x as selective inhibitors of P-selectin, we have designed a mannosyl terpenoid derivative that selectively inhibits P-selectin within an IC50 value of 60 μM, but exhibits no inhibition activity against E- and L-selectins.
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(1996)
