Design and synthesis of an α-mannosyl terpenoid as selective inhibitor of P-selectin

Article abstract of DOI:10.1016/S0960-894X(97)10022-1

In an effort to develop the structural and functional mimics of the tetrasaccharide sialyl Lewis x as selective inhibitors of P-selectin, we have designed a mannosyl terpenoid derivative that selectively inhibits P-selectin within an IC₅₀ value of 60 μM, but exhibits no inhibition activity against E- and L-selectins.