Studies on hypotensive agents. Synthesis of 1-substituted 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)- quinazolinediones

DOI: 10.1248/cpb.39.1753

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1753 - 1759 (1991)

Update date:2022-07-30

Topics:

Authors:

Eguchi Eguchi

Sasaki Sasaki

Sugimoto

Ebisawa Ebisawa

Ishikawa

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Article abstract of DOI:10.1248/cpb.39.1753

3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)- quinazolinedione was newly prepared. 1-Hydrogen atoms of the compound were variously substituted in order to test for their hypotensive activities on relaxing effects of the blood vessels. The compounds with 2-(1-pyrrolidinyl ethyl, 2-(1-piperidinyl)ethyl, 3-(dimethylamino)propyl, and 3-(N-benzyl-N-methylamino)propyl moieties showed significant activity. The 2-(1-piperidinyl)ethyl compound possessed activity approximately 23 times more potent than papaverine, however, it was less potent than cinnarizine.

Full text of DOI:10.1248/cpb.39.1753

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