Fused cyanopyrimidines: Part II synthesis and reactions of fused cyanopyrimidine derivatives as affecting enzymatic agents

Article abstract of DOI:10.1080/10426509608046379

Some new fused heterobicyclic systems, such as thiazolo[3,2-a]-pyrimidin-5-one (3), 2,3-tetrahydrothiazolo[3,2-a]pyrimidin-5-one (5), 2,4-tetrahydrothiazino[3,2-a]pyrimidin-3,6-dione (6), 3-dihydrothiazino[3,2-a]pyrimidin-2,4,6-trione (7), 3-arylidenethiazino[3,2-a]pyrimidin-2,4,6-trione (8) and/or the related nitrogen compounds, such as 2,3-tetrahydroimidazolo[3,2-a]-pyrimidin-5-one(9), 1-aryl-2,3-tetrahydroimidazolo[3,2-a]pyrimidin-5-one (11), quinazolino[3,2-a]pyrimidin-6,8-dione (12) and 3-mercapto-1,2,4-triazolo[4,3-a]pyrimidin-5-one (14) have been synthesized by the interaction of 2-mercapto-4-arylidene-5-cyanopyrimidin-6(1H)one (1) with α,β-bifunctional nitrogen, oxygen and/or sulfur compounds. The structures have been characterized by elemental analyses, IR, UV, ¹H NMR and mass spectral data. Some newly prepared compounds revealed a moderate effect on the activity of cellobiase produced by Aspergillus nidulans.

Full text of DOI:10.1080/10426509608046379

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Phosphorus, Sulfur, and Silicon and the
Related Elements
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FUSED CYANOPYRIMIDINES: PART II
SYNTHESIS AND REACTIONS OF FUSED
CYANOPYRIMIDINE DERIVATIVES AS
AFFECTING ENZYMATIC AGENTS
S. A. Abdel-aziz a , H. A. Allimony a , H. M. El-shaaer a , Usama F. Ali
b & R. M. Abdel-rahman a
a Department of Chemistry, Faculty of Education, Ain-Shams
University, Roxy, Cairo, Egypt
b Department of Biological & Geological Sciences, Faculty of
Education, Ain-Shams University, Roxy, Cairo, Egypt
Published online: 04 Oct 2006.
To cite this article: S. A. Abdel-aziz , H. A. Allimony , H. M. El-shaaer , Usama F. Ali & R. M.
Abdel-rahman (1996) FUSED CYANOPYRIMIDINES: PART II SYNTHESIS AND REACTIONS OF FUSED
CYANOPYRIMIDINE DERIVATIVES AS AFFECTING ENZYMATIC AGENTS, Phosphorus, Sulfur, and Silicon and
the Related Elements, 113:1-4, 67-77
To link to this article: http://dx.doi.org/10.1080/10426509608046379
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