Bioorganic and Medicinal Chemistry Letters p. 1719 - 1724 (1996)
Update date:2022-07-30
Topics:
Robinson, Ralph P.
Ragan, John A.
Cronin, Brian J.
Donahue, Kathleen M.
Lopresti-Morrow, Lori L.
Mitchell, Peter G.
Reeves, Lisa M.
Yocum, Sue A.
The effect of P1' Cα gem-disubstitution in a series of succinamide hydroxamate inhibitors of MMP-1 has been investigated. While in all cases P1' gem-disubstitution led to loss of potency relative to the corresponding P1' isobutyl and phenyl compounds 1 and 3, respectively, the loss of activity was less pronounced in certain instances, e.g., the P1' gem-cyclohexyl analogue 12 (IC50 = 0.15 μM).
View MoreZhejiang Sanmei Chemical Industry Co., Ltd
Contact:86-579-87633213
Address:Huchu Industrial Zone, Qingnian Rd., Wuyi County, Zhejiang Prov., China.
website:http://www.shtopchem.com/
Contact:0086-0576-87776998
Address:room no 1608,xuhui business building yude road,xujiahui street, xuhui district
Shanghai Kefu Chemical Co.,Ltd.
Contact:+86-21-34616196
Address:Room601-602, Xuhui Business Building, No.168, Yude Road, Shanghai
Shanghai Sinofluoro Scientific Co., Ltd
Contact:+86-21-64279360
Address:Room 1006,Building 3,#58 East Xinjian Road, Shanghai ,201100,China,
Changzhou BaoKang Pharmaceutical & Chemical Co., Ltd
Contact:(86) 519-88782201 88784080 88785278
Address:Henglin town, changzhou,Jiangsu
Doi:10.1016/S0968-0896(96)00266-0
(1997)Doi:10.1039/DT9960003411
(1996)Doi:10.1080/00397919608003791
(1996)Doi:10.1016/0040-4039(96)01199-9
(1996)Doi:10.1016/0040-4020(96)00688-6
(1996)Doi:10.1016/0040-4039(96)01520-1
(1996)
