Synthesis and evaluation of water-soluble non-prodrug analogs of docetaxel bearing sec-aminoethyl group at the C-10 position

DOI: 10.1248/cpb.46.770

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 770 - 776 (1998)

Update date:2022-08-02

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Authors:

Uoto, Kouichi

Takenoshita, Haruhiro

Yoshino, Toshiharu

Hirota, Yasuhide

Ando, Shuichi

Mitsui, Ikuo

Terasawa, Hirofumi

Soga, Tsunehiko

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Article abstract of DOI:10.1248/cpb.46.770

To develop non-prodrugs of taxoids with satisfactory stability in vivo, high water-solubility, and potent antitumor activity, we prepared several 10- O-sec-aminoethyl docetaxel analogs (3) and evaluated their cytotoxicity against mouse leukemia and human

Full text of DOI:10.1248/cpb.46.770

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Product name:10-O-allyl-10-deacetyl-7-O-triethylsilylbaccatin III

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