Synthesis and evaluation of water-soluble non-prodrug analogs of docetaxel bearing sec-aminoethyl group at the C-10 position

DOI: 10.1248/cpb.46.770

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 770 - 776 (1998)

Update date:2022-08-02

Topics:

Authors:

Uoto, Kouichi

Takenoshita, Haruhiro

Yoshino, Toshiharu

Hirota, Yasuhide

Ando, Shuichi

Mitsui, Ikuo

Terasawa, Hirofumi

Soga, Tsunehiko

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.46.770

To develop non-prodrugs of taxoids with satisfactory stability in vivo, high water-solubility, and potent antitumor activity, we prepared several 10- O-sec-aminoethyl docetaxel analogs (3) and evaluated their cytotoxicity against mouse leukemia and human

Full text of DOI:10.1248/cpb.46.770

NII-Electronic Library Service

Products guided by the article

Product name:10-O-allyl-10-deacetyl-7-O-triethylsilylbaccatin III

Cas No:181419-93-2

R&D Labs maybe for 181419-93-2

New Forms

Contact:+31-24-3886056

Address:Binderskampweg 29 Unit 36
Jintan Jinnuo Chemical Co., Ltd.

Contact:+86-519-80199901

Address:Room 1804, Building 1, Huacheng Business Plaza, Jintan, Jiangsu, China
SINO GREAT ENTERPRISE LTD.

Contact:+86-731-84427351

Address:154 JIANXIANG SOUTH ROAD
Anhui Sunsing Chemicals Co.,Ltd

website:http://www.sunsingchem.com

Contact:0086-566-2023179

Address:Jin An industry park, Chizhou economic technical development zone, Anhui
Nanjing lanbai chemical Co.,Ltd.

Contact:+86-25-85499326

Address:Room 908, 9F Taiyue Building,No.285 Heyan Road

Relevant to this article

Copper-Catalyzed Asymmetric Addition of Tertiary Carbon Nucleophiles to 2 H-Azirines: Access to Chiral Aziridines with Vicinal Tetrasubstituted Stereocenters

Doi:10.1021/acs.orglett.8b02274
(2018)
The relationship between transannular secondary bonding strength and conformation in diphenyldithiophosphinate stibocanes X(CH₂CH₂S)₂SbS₂PPh₂ (X = O, S)

Doi:10.1002/zaac.19966220819
(1996)
Efficient Synthesis of 5-Carboxanilide-Dihydropyrimidinones Using Cobalt(II) Nitrate Hexahydrate

Doi:10.1002/jccs.201600841
(2017)
A novel, stereocontrolled approach to ring B alkylated estratetraenes

Doi:10.1016/0040-4039(96)01342-1
(1996)
Lewis acid-mediated nucleophilic alkylations on chiral [6,3a,4]oxadiazaindano[5,4-a]isoquinolines. Asymmetric synthesis of 1-alkyl substituted tetrahydroisoquinolines

Doi:10.1016/0040-4039(96)01337-8
(1996)
Bis(tetramethylcyclopentadienyl)titanium chemistry. Molecular structures of [(C₅HMe₄)(μ-η¹:η⁵-C ₅Me₄)Ti]₂ and [(C₅HMe₄)₂Ti]₂N₂

Doi:10.1021/om960509w
(1996)

Article Doi