Highly regio- and stereo-selective alkyl substitution with copper reagents for the construction of chiral trifluoromethylated quaternary carbon centres

DOI: 10.1039/a703223d

Source and publish data:

Chemical Communications p. 1497 - 1498 (1997)

Update date:2022-08-03

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Authors:

Hiraoka, Shuichi

Yamazaki, Takashi

Kitazume, Tomoya

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Article abstract of DOI:10.1039/a703223d

A new route for the asymmetric construction of quaternary carbon centres containing a trifluoromethyl group has been established using a highly regio- and stereo-selective S_N2′ reaction of organocopper and organocuprate reagents with allylic mesylates 4 and 8.

Full text of DOI:10.1039/a703223d

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